Iodine Redistribution During Trauma, Sepsis, and Hibernation: An Evolutionarily Conserved Response to Severe Stress

SLR-2 and JMJC-1 regulate an evolutionarily conserved stress-response network.

Maintaining a homeostatic interaction with the environment is crucial for the growth, survival, and propagation of all living organisms. Reestablishment of equilibrium after stress is achieved by the activation of complex transcriptional-response networks, many of which remain poorly understood. Here, we report that the zinc-finger protein, SLR-2, is a master stress regulator and is required fo...

The Adaptive Response to Intestinal Oxidative Stress in Mammalian Hibernation

Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response

In eukaryotic cells, diverse stresses trigger coalescence of RNA-binding proteins into stress granules. In vitro, stress-granule-associated proteins can demix to form liquids, hydrogels, and other assemblies lacking fixed stoichiometry. Observing these phenomena has generally required conditions far removed from physiological stresses. We show that poly(A)-binding protein (Pab1 in yeast), a def...

Cardiovascular response to dobutamine stress predicts outcome in severe sepsis and septic shock

INTRODUCTION During septic shock, resistance to the haemodynamic effects of catecholamine vasopressors and inotropes is a well-recognised marker of mortality risk. However, the specific cardiovascular or metabolic response elements that are most closely associated with outcome have not been well defined. The objective of this study was to assess cardiovascular and metabolic responses to dobutam...

Stress, Trauma, Sepsis, Inflammation, Management in Asthma

This review paper covered stress, management related to asthma, trauma, sepsis, infl ammation along with anxiety, and depression that occurs both in women with asthma, traumatic children and adult patients. These areas, induce immune function changes, which can lead to both trauma and proinfl ammatory activation known as systemic infl ammation response syndrome (SIRS). Related to sepsis. Stress...